The active ingredient in Zombie Cell Detox is Fisetin (100 mg derived from Rhus Succedanea stem), which is the finest thoroughbred horse in the senolytics stable, destroying dysfunctional senescent cells and extending lifespan by approximately 10% in animal studies.
It is a plant flavonol from the flavonoid group of polyphenols. These are a hot anti-oxidant group of compounds! Fisetin can be found in many fruits and vegetables, where it serves as a yellow/ochre coloring agent, such as in strawberries*, apples, persimmons, onions and cucumbers.
There is a lot more to fisetin than just life extension.
Anti-Inflammatory and Other Beneficial Effects
In line with its role as a flavonol, fisetin has powerful anti-oxidant and therefore anti-inflammatory effects. Fisetin can reduce markers of inflammation, benefitting joints and other tissues.
Fisetin treatment can also reduce cellular aging in kidney, liver, fat, and spleen, and reduce levels of circulating senescence-associated secretory phenotype (SASP) factors (don’t even ask!).
Fisetin even has a role against cancer, according to a Science Direct review. It helped induce cellular apoptosis (programmed cell death), alone and in conjunction with a chemo-gent: cisplatin. This was against deadly lung cancer cells, so that could be important to many of us.
A 2014 study described various flavonoids, such as apigenin, baicalein, cyanidin, fisetin, galangin, hesperetin, luteolin, myricetin, naringenin, phloretin and quercetin, as quite potent inhibitors of DNA methyltransferase activity (that’s good—tumor cells typically exhibit aberrant DNA methylation patterns during malignant transformation)
Mimicking Caloric Restriction
Reducing food intake through a calorie-restricted diet has been shown to slow aging, extend lifespan, and improve resistance to disease.
There are 3 main ways that fisetin can help with weight control…
1) Reduces the activity of mTOR (mammalian target of rapamycin), a remarkable substance linked to aging, weight gain, and chronic disease.
2) Boosts the function of sirtuins (remember resveratrol and that story?)
3) It helps flip the “fat switch” to OFF, by increasing the activity of the enzyme AMPK.
Fisetin not only has the ability to extend lifespan in preclinical models, it may also reduce the risk for many of the most common chronic illnesses.
Heart disease remains the leading cause of death in the U.S. Most common forms of heart disease are due to inadequate flow of blood, oxygen, and nutrients to the heart, which can lead to a heart attack.
Over the last two years, studies have demonstrated that fisetin can protect the heart from injury. Even after heart attack models, heart cells fare better when fisetin is present.
In one recent study published in the journal Nature, rat heart cells starved for nutrients and oxygen were protected by fisetin, preventing cell death.
And in animal models of heart attack, the extent of heart damage was reduced when treated with fisetin, preserving better heart function.
Zombie Cell Detox
As a dietary supplement take One veggie capsule daily with water